Public Health Resources

Could CRISPR Gene-Editing Technology Be an Answer to Chronic Pain?   - Could a version of the CRISPR gene-editing tool also help deliver long-lasting pain relief without the risk of addiction associated with prescription opioid drugs? In work recently published in the journal Science Translational Medicine, researchers demonstrated in mice that a modified version of the CRISPR system can be used to “turn off” a gene in critical neurons to block the transmission of pain signals. (National Institutes of Health (NIH), HHS)

NIH-funded project creates an encyclopedia detailing the inner workings of the human and mouse genomes   - ENCODE Project's third phase offers new insights into the organization and regulation of our genes and genome. (National Institutes of Health (NIH), HHS)

COVID-19 Prevention Network   - The COVID-19 Prevention Network (CoVPN) was formed by the National Institute of Allergy and Infectious Diseases (NIAID) at the US National Institutes of Health to respond to the global pandemic. Using the infectious disease expertise of their existing research networks and global partners, NIAID has directed the networks to address the pressing need for vaccines and monoclonal antibodies (mAbs) against SARS-CoV-2. (National Institute of Allergy and Infectious Diseases (NIAID), NIH)

bioinformatics @NIAID   - Portal brings together some exciting features including: links to extensive training resources; a section of scripts, code, and programs created by NIAID researchers downloadable from GitHub; and a curated calendar of events with entries focused on bioinformatics and computational biology. (National Institute of Allergy and Infectious Diseases (NIAID), NIH)

Coronavirus Disease Portal   - Page provides up-to-date genomics and precision health information on Coronavirus. (Centers for Disease Control and Prevention (CDC), HHS)

Coronavirus genomes – NCBI Datasets   - Download datasets containing viral genome and protein sequences, annotation and a data report. (National Center for Biotechnology Information (NCBI), NLM)

Database of Genotypes and Phenotypes (dbGaP)   - dbGaP was developed to archive and distribute the results of studies that have investigated the interaction of genotype and phenotype. Such studies include genome-wide association studies, medical sequencing, molecular diagnostic assays, as well as association between genotype and non-clinical traits.

Global Salmonella Resistome Data   - Tool provides visually informative displays of antibiotic resistance genes in bacteria. It is designed mainly for public health officials, academics and researchers who are using new genomics technologies to track and treat infectious diseases. (U.S. Food & Drug Administration (FDA), HHS)

HuGE Navigator   - HuGE Navigator provides access to a continuously updated knowledge base in human genome epidemiology, including information on population prevalence of genetic variants, gene-disease associations, gene-gene and gene- environment interactions, and evaluation of genetic tests. (Centers for Disease Control and Prevention (CDC), HHS)

Human Genome Resources   - Portal provides access to genome visualization and analysis tools, BLAST, NCBI Genome Remapping Service, and molecular databases. (National Center for Biotechnology Information (NCBI), NLM)

Influenza Virus Resource - National Center for Biotechnology Information   - A browsing tool allows you to compare the sequenced variations of the influenza virus genome. (National Library of Medicine (NLM), NIH)

National Newborn Screening & Global Resource Center   - An independent U.S. national resource center for newborn screening as well as global newborn screening information. Site provides consultative services, program reviews, selected national data, hosts a respected international discussion listserv, and provides information and resources for health professionals, consumers, public health professionals, and others.

Newborn Screening Coding and Terminology Guide   - Includes standard codes and terminology for newborn tests for the conditions recommended for screening by the Advisory Committee on Heritable Disorders in Newborns and Children (ACHDNC) or by a state within the U.S. (National Library of Medicine (NLM), NIH)

Nextstrain   - Nextstrain is an open-source project to harness the scientific and public health potential of pathogen genome data. Site provides a continually-updated view of publicly available data with powerful analytics and visualizations showing pathogen evolution and epidemic spread, with the goal of aiding epidemiological understanding and improving outbreak response. (nextstrain)

PhenX Toolkit   - The toolkit provides standard measures related to complex diseases, phenotypic traits and environmental exposures. Use of PhenX measures facilitates combining data from a variety of studies, and makes it easy for investigators to expand a study design beyond the primary research focus. (National Human Genome Research Institute)

Public Health Genomics and Precision Health Knowledge Base   - An online, continuously updated, searchable database of published scientific literature, CDC resources, and other materials that address the translation of genomic discoveries into improved health care and disease prevention. (Centers for Disease Control and Prevention (CDC), HHS)

U.S. Genome Variation Estimates - National Office of Public Health Genomics   - These variation estimates are the allele frequency and genotype prevalence estimates of human genetic variants for the entire U.S. population based on DNA data collected from participants in the Third National Health and Nutrition Examination Survey (NHANES III). (Centers for Disease Control and Prevention (CDC), HHS)

APHL-CDC Bioinformatics Fellowship   - The APHL-CDC Bioinformatics Fellowship aims to train and prepare bioinformaticians to apply their expertise within public health and design tools to aid existing public health personnel in the use of bioinformatics. The Bioinformatics Fellowships provide post-master’s and post-doctoral level professionals the opportunity to apply their skills to a range of important and emerging public health problems, while gaining experience in their fields. (Association of Public Health Laboratories)

APHL-CDC Newborn Screening Bioinformatics and Data Analytics Fellowship   - This fellowship aims to train and prepare bioinformaticians to apply their expertise within public health and design tools to aid existing public health personnel in the use of bioinformatics. Its mission is to provide a high quality training experience for fellows while providing workforce capacity to the public health laboratory community. (Association of Public Health Laboratories)

Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)   - This Funding Opportunity Announcement (FOA) invites Research Project Grant (R01) applications that propose to study the ethical, legal and social implications (ELSI) of human genome research. (National Institutes of Health (NIH), HHS)

Genetics & Public Policy Fellowship   - The American Society of Human Genetics (ASHG) and the National Human Genome Research Institute (NHGRI) co-sponsor the Genetics and Public Policy Fellowship to give genetics professionals an opportunity to contribute to the policy-making process. The fellowship is designed as a bridge for genetics professionals wishing to transition to a policy career. (American Society of Human Genetics)

Genetics Education & Engagement Fellowship   - Fellowship to give early career genetics professionals an opportunity to contribute to the development and implementation of national genomics literacy efforts, informal science education, science education policy, program development, and science education research. (American Society of Human Genetics)

Genomic Community Resources (U24 Clinical Trial Not Allowed)   - To facilitate genomic research and the dissemination of its products, NHGRI supports genomic resources that are crucial for basic research, disease studies, model organism studies, and other biomedical research. Awards under this FOA will support the development and distribution of genomic resources that use cost-effective approaches and will be valuable for the broad research community. (National Human Genome Research Institute)

Innovations in Newborn Screening Interoperability   - The purpose of this initiative is to support state newborn screening programs in assessing their current capacity in achieving interoperability, developing a comprehensive plan, and beginning to implement their plan. (Health Resources and Services Administration (HRSA), HHS)

Investigator Initiated Research in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)   - The purpose of this funding opportunity announcement (FOA) is to invite applications for a broad range of research efforts in computational genomics, data science, statistics, and bioinformatics relevant to one or both of basic or clinical genomic science, and broadly applicable to human health and disease. (National Human Genome Research Institute)

Investigator Initiated Research in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)   - The purpose of this funding opportunity announcement (FOA) is to invite applications for a broad range of research efforts in computational genomics, data science, statistics, and bioinformatics relevant to one or both of basic or clinical genomic science, and broadly applicable to human health and disease. (National Human Genome Research Institute)

Omics-guided Biobehavioral Interventions for Improved Health Outcomes: A Step Forward in Translation (R01 Clinical Trial Optional)   - The purpose of this funding opportunity announcement (FOA) is to stimulate clinical research that harnesses the wealth of advances in the fields of genomics and other omics (e.g., metabolomics, microbiomics, proteomics, transcriptomics, epigenomics, etc.) to incorporate these advances into translatable, personalized biobehavioral interventions for improved health outcomes. (National Institute of Nursing Research (NINR), NIH)

Social Epigenomics Research Focused on Minority Health and Health Disparities (R01-Clinical Trial Not Allowed)   - Funding for investigations focused on identifying and characterizing the mechanisms by which social experiences at various stages in life, both positive and negative, affect gene function and thereby influence health trajectories or modify disease risk in racial/ethnic minority and health disparity populations. (National Institutes of Health (NIH), HHS)

State Newborn Screening Interoperability Planning Program   - The purpose of this initiative is to support state newborn screening programs in assessing their current interoperability and informatics capacity, developing a comprehensive plan to achieve data capacity, and beginning implementation of their plan. (Health Resources and Services Administration (HRSA), HHS)

Genetic Information Nondiscrimination Act (GINA) of 2008 - United States   - (National Human Genome Research Institute)

Genetic Testing and Screening in the Age of Genomic Medicine   - Provides summary information and recommendations from the New York State Task Force on Life and the Law about genetic testing. (New York State Department of Health)

Genome Statute and Legislation Database   - Database is comprised of state statutes and bills introduced during the 2007-2018 U.S. state legislative sessions. The database is reviewed and updated monthly. Searchable topics in the database include employment and insurance discrimination, health insurance coverage, privacy, research, the use of residual newborn screening specimens, and other topics of interest. (National Human Genome Research Institute)

Newborn Screening Legislation   - Page provides overviews of legislation related to genetic disease screening for infants. (Baby's First Test Newborn Screening Clearinghouse)

Resources for State Genetics Planning   - (National Newborn Screening & Global Resource Center (NNSGRC))

Genetic Alliance Disease InfoSearch   - Electronic collection of documents, links, audio and video files in topic areas such as newborn screening, family health history, genetic testing, reimbursement, research, drug development, community engagement, and organizational development. (Genetic Alliance)

Genomics & Health Impact Scan Database   - Database includes published scientific literature on evidence-based translation of genomic discoveries into improved health care and disease prevention that have a potential impact on population health. (Centers for Disease Control and Prevention (CDC), HHS)

Genomics Publications   - Publications from CDC's Office of Public Health Genomics (OPHG) including annual reports, books, and scientific articles. (Centers for Disease Control and Prevention (CDC), HHS)

Human Genome Editing: Science, Ethics, and Governance (2017)   - Report considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. (National Academies of Science, Engineering, and Medicine (NASEM))

Implications of Genomics for Public Health - Committee on Genomics and the Public's Health in the 21st Century   - This 2005 workshop report summarizes speaker presentations on major scientific and policy issues related to genomics and public health, major supports for and challenges to the translation of genetic research into population health benefits, and approaches for the integration of genomic information into strategies for promoting health and preventing disease. It was funded by a contract from the Centers for Disease Control and Prevention, Office of Genomics and Disease Prevention. (National Institute of Medicine)

Information for Laboratories about Coronavirus (COVID-19)   - COVID-19 resources for laboratories on diagnostic tests, antibody tests, biosafety, reporting data, and guidance for safety practices. (Centers for Disease Control and Prevention (CDC), HHS)

PHG Foundation Reports   - Published reports and academic papers on public health genomics topics. (PHG Foundation)

Precision Public Health for the Era of Precision Medicine   - Article outlines how the same technologies used for precision medicine can be harnessed for precision public health. (American Journal of Preventive Medicine)

STrengthening the REporting of Genetic Association Studies (STREGA)- An Extension of the STROBE Statement - PloS Medicine   -

The 2010 State Public Health Genomics Resource Guide   - This is the 2nd edition of the Guide; it looks at innovative approaches and challenges by states to integrate genomics into their public health programs. (Association of State and Territorial Health Officials (ASTHO))

GeneEd   - Resource for students and teachers to learn about genetics. The website allows users to explore topics such as Cell Biology, DNA, Genes, Chromosomes, Heredity/Inheritance Patterns, Epigenetics/Inheritance and the Environment, Genetic Conditions, Evolution, Biostatistics, Biotechnology, DNA Forensics, and Top Issues in Genetics. (National Human Genome Research Institute)

Genomics and Health Impact Blog   - Blog on the results of genomic research, evaluation, and programs conducted by CDC and other institutions around the world from a public health perspective. (Centers for Disease Control and Prevention (CDC), HHS)

MedlinePlus Genetics   - Genetics Home Reference is the National Library of Medicine's web site for consumer information about genetic conditions and the genes or chromosomes responsible for those conditions. (National Library of Medicine (NLM), NIH)

My Family Health Portrait   - Internet-based family health history tool that makes it easy for consumers to assemble and share family health history information within the family and with health care practitioners. Better use of health history information can support more informed and personalized patient care. (Office of the Surgeon General, HHS)

Plain Language Recommendations for Reporting Newborn Screening Results   - This one-pager includes guidelines on how to create clear reports to communicate newborn screening results, including language and design recommendations. (Baby's First Test Newborn Screening Clearinghouse)

Talking Glossary of Genetic Terms   - Learning tool to help explain the terms and concepts used in genetic research. The glossary includes descriptions of genetic terms, images, animation, and links to related terms. (National Human Genome Research Institute)

American Society of Human Genetics Meetings   - (American Society of Human Genetics)

Colloquia Series on Personalized Medicine   - The colloquia addresses the scientific discoveries, business models, and regulatory changes that are necessary to develop new personalized treatments and their companion diagnostics. (American Association for the Advancement of Science)

Genetic Alliance Events   - Events and webinars focusing on topics in health and genetics. (Genetic Alliance)

Genomics and Health Disparities Lecture Series   - A series of lectures aimed at discussing how innovations in genomics research and technology can impact health disparities. (National Human Genome Research Institute)

Public Health Genomics Upcoming Events   - List of selected upcoming genomics-related events. (Centers for Disease Control and Prevention (CDC), HHS)